Ceftezole supplier in China CAS NO.26973-24-0

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1. Introduction of Ceftezole

Ceftezole(CAS: 26973-24-0), has the systematic name of (6R,7R)-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. The chemical formula of this chemical is C13H12N8O4S3 and the molecular weight is 440.48.
 

2. Basic Information of Ceftezole

1). Properties of Ceftezole

Physical properties of Ceftezole: (1)ACD/LogP: 0.87; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.98; (4)ACD/LogD (pH 7.4): -2.84; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 12; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 215.14 ?2; (13)Index of Refraction: 2.003; (14)Molar Refractivity: 105.33 cm³; (15)Molar Volume: 210.2 cm³; (16)Polarizability: 41.75×10-24cm³; (17)Surface Tension: 119.4 dyne/cm.

2). Descriptors of Structure
You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cn3nnnc3)CSc4nncs4)C(=O)O
(2)InChI: InChI=1/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1
(3)InChIKey: DZMVCVMFETWNIU-LDYMZIIABU
(4)Std. InChI: InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1
(5)Std. InChIKey: DZMVCVMFETWNIU-LDYMZIIASA-N
 

3) Drug Interactions of Ceftezole

Renal excretion inhibited by probenecid. Bacteriostatic antibacterials.
Potentially Fatal: Nephrotoxic drug eg. aminoglycoside may increase risk of kidney damage. Enhanced nephrotoxicity with a loop diuretic.

4) Mechanism of Action

Ceftezole has properties similar to cefalotin. It is active against S. aureus, S. pneumoniae, E. coli, Proteus mirabilis.

5) Adverse Drug Reactions of Ceftezole

Nausea; vomiting; diarrhea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; hematologic disorders; pain at injection site (IM); thrombophlebitis (IV infusion); superinfection with prolonged use.
 

6) Package and storage

Package: Sealed export grade drum & double of sealed plastic bag.

Storage: Store in cool & dry place not freeze., keep away from strong light and heat.