Methylthiouracil 98% supplier in China CAS NO.56-04-2

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1.Introduction of Methylthiouracil

Methylthiouracil is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.Methylthiouracil is not used clinically in the United States, it has a similar mechanism of action and side effect to that of propylthiouricil.The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.The clinical effects of the drug to treat the hyperthyroid state can have a lag period of up to two weeks, depending on the stores of thyroglobulin and other factors
 

2.Properties of Methylthiouracil

(1)ACD/LogP: -1.386  (2)# of Rule of 5 Violations: 0

(3)ACD/LogD (pH 5.5): -3.94  (4)ACD/LogD (pH 7.4): -4.84

(5)ACD/BCF (pH 5.5): 1.00  (6)ACD/BCF (pH 7.4): 1.00

(7)ACD/KOC (pH 5.5): 1.00  (8)ACD/KOC (pH 7.4): 1.00

(9)#H bond acceptors: 3  (10)#H bond donors: 1

(11)Polar Surface Area: 84.81 ?2 (12)Index of Refraction: 1.638

(13)Molar Refractivity: 37.317 cm3 (14)Molar Volume: 103.196 cm3

(15)Polarizability: 14.794 10-24cm3 (16)Surface Tension: 68.3550033569336 dyne/cm 

(17)Density: 1.378 g/cm3 (18)Flash Point: 160.834 °C  (19)Enthalpy of Vaporization: 60.926 kJ/mol

(20)Boiling Point: 342.327 °C at 760 mmHg

3.Structure descriptors of Methylthiouracil

SMILES:O=C1\C=C(/NC(=S)N1)C

Std. InChI:InChI=1S/C5H6N2OS/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9) 

Std. InChIKey:HWGBHCRJGXAGEU-UHFFFAOYSA-N
 

4.Side effects of Methylthiouracil

Like with any drug a wide variety of side effects can occur, but four topics should be kept in mind and the patient informed:Agranulocytosis - develops rapidly, sore throat and fever are hallmark symptoms. Can be fatal if drug is not discontinued promptly.Allergic skin reactions the most dangerous of which is Exfoliative Dermatitis, it rapidly can get out of control, notify the physician should a skin eruption occur.Hepatitis - yellowing of the skin, nausea, yellowing of the whites of the eyes, flu-like symptoms.Thrombocytopenia - unusual bruising or bleeding.