Benzocaine 98% supplier in China CAS NO.94-09-7

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1.Introduction of Benzocaine

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B Otic Drops to relieve ear pain and remove earwax.

2.Properties of Benzocaine

(1)ACD/LogP: 1.945  (2)# of Rule of 5 Violations: 0
(3)ACD/LogD (pH 5.5): 1.95  (4)ACD/LogD (pH 7.4): 1.95
(5)ACD/BCF (pH 5.5): 17.70  (6)ACD/BCF (pH 7.4): 17.72
(7)ACD/KOC (pH 5.5): 272.13  (8)ACD/KOC (pH 7.4): 272.41
(9)#H bond acceptors: 3  (10)#H bond donors: 2
(11)#Freely Rotating Bonds: 4  (12)Polar Surface Area: 52.32  2
(13)Index of Refraction: 1.554  (14)Molar Refractivity: 46.895 cm3
(15)Molar Volume: 146.113 cm3  (16)Polarizability: 18.591 10-24cm3
(17)Surface Tension: 44.6710014343262 dyne/cm (18)Density: 1.131 g/cm3
(19)Flash Point: 164.199 °C  (20)Enthalpy of Vaporization: 55.159 kJ/mol
(21)Boiling Point: 310.731 °C at 760 mmHg  (22)Vapour Pressure: 0.00100000004749745 mmHg at 25°C
 

3.Structure descriptors of Benzocaine

SMILES:O=C(OCC)c1ccc(N)cc1

Std. InChI:InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3

Std. InChIKey:BLFLLBZGZJTVJG-UHFFFAOYSA-N

4.Mechanism of action

Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential. The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Esters of PABA work as a chemical barrier, stopping the sodium from entering the nerve ending.

5.Application of Benzocaine

Benzocaine is used as a key ingredient in numerous pharmaceuticals:

  Over the counter throat lozenges such as Cepacol, Life Brand Oral Anaesthetic.
   Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as Otitis Media and swimmers ear.
   Some previous diet products such as Ayds.
   Some condoms designed to prevent premature ejaculation. Benzocaine acts to desensitize the penis, and theoretically allows an erection to be maintained.

Benzocaine is used in abalone aquaculture. The strong muscular foot which the abalone use to hold on to the rocks in the wild makes handling the animals difficult. Abalone farmers use benzocaine to mildly anaesthetise them, resulting in the animals loosening their tight grip on the substrate. This enables the farmers to more easily remove them and move them around the farm.[citation needed]

Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine. Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine.